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The 10 Most Valuable 2025 Panini Prizm Significant Signature Football Cards

The most valuable 2025 Panini Prizm Significant Signature Football card is the 2025 Panini Prizm Significant Signature Shedeur Sanders #SSI-SSS at $37.48 as of October 20, 2026.

By Ripbin Research · Updated 2026-10-20 · prices from live market data

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The 10 most valuable 2025 Panini Prizm Significant Signature Football cards in the Ripbin catalog (2026) carry a combined raw market value of $222.27, topped by a $37.48 card.

  1. 2025 Panini Prizm Significant Signature Shedeur Sanders #SSI-SSS

    #12025 Panini Prizm Significant Signature Shedeur Sanders #SSI-SSS

    $37.48PSA 10 ~$182.50
    Full price guide →See eBay listings ↗
  2. 2025 Panini Prizm Significant Signature Travis Hunter #SSI-THR

    #22025 Panini Prizm Significant Signature Travis Hunter #SSI-THR

    $35.00PSA 10 ~$150.00
    Full price guide →See eBay listings ↗
  3. 2025 Panini Prizm Significant Signature Rome Odunze #SSI-ROE

    #32025 Panini Prizm Significant Signature Rome Odunze #SSI-ROE

    $28.22PSA 10 ~$160.21
    Full price guide →See eBay listings ↗
  4. 2025 Panini Prizm Significant Signature Javonte Williams #SSI-JAW

    #42025 Panini Prizm Significant Signature Javonte Williams #SSI-JAW

    $25.00PSA 10 ~$133.96
    Full price guide →See eBay listings ↗
  5. 2025 Panini Prizm Significant Signature Upton Stout #SSI-UST

    #52025 Panini Prizm Significant Signature Upton Stout #SSI-UST

    $20.82PSA 10 ~$123.63
    Full price guide →See eBay listings ↗
  6. 2025 Panini Prizm Significant Signature Juice Scruggs #SSI-JSS

    #62025 Panini Prizm Significant Signature Juice Scruggs #SSI-JSS

    $19.99
    Full price guide →See eBay listings ↗
  7. 2025 Panini Prizm Significant Signature Rocky Bleier #SSI-RBR

    #72025 Panini Prizm Significant Signature Rocky Bleier #SSI-RBR

    $19.99PSA 10 ~$117.28
    Full price guide →See eBay listings ↗
  8. 2025 Panini Prizm Significant Signature Darnell Washington #SSI-DWN

    #82025 Panini Prizm Significant Signature Darnell Washington #SSI-DWN

    $15.12PSA 10 ~$80.03
    Full price guide →See eBay listings ↗
  9. 2025 Panini Prizm Significant Signature Jack Sawyer #SSI-JSR

    #92025 Panini Prizm Significant Signature Jack Sawyer #SSI-JSR

    $10.65PSA 10 ~$78.55
    Full price guide →See eBay listings ↗
  10. 2025 Panini Prizm Significant Signature Barryn Sorrell #SSI-BSL

    #102025 Panini Prizm Significant Signature Barryn Sorrell #SSI-BSL

    $10.00PSA 10 ~$71.59
    Full price guide →See eBay listings ↗

Just missed the cut

Players in this guide

Shedeur Sanders cardsTravis Hunter cardsRome Odunze cardsJavonte Williams cardsUpton Stout cardsJuice Scruggs cardsRocky Bleier cardsDarnell Washington cardsJack Sawyer cardsBarryn Sorrell cardsDan Dierdorf cardsRiley Leonard cards

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Full 2025 Panini Prizm Significant Signature Football checklist →Card investing reports →
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