The 10 Most Valuable 2021 Topps Opening Day Base Set Baseball Cards
The most valuable 2021 Topps Opening Day Base Set Baseball card is the 2021 Topps Opening Day Base Set Juan Soto #213 at $50.50 as of October 3, 2026.
By Ripbin Research · Updated 2026-10-03 · prices from live market data
Shop 2021 Topps Opening Day Base Set Baseball cards on eBay
Affiliate — we may earn a commissionThe 10 most valuable 2021 Topps Opening Day Base Set Baseball cards in the Ripbin catalog carry a combined raw market value of $90.36, topped by a $50.50 card.
#12021 Topps Opening Day Base Set Juan Soto #213
$50.50PSA 10 ~$163.75
#42021 Topps Opening Day Base Set Aaron Judge #99
$1.99PSA 10 ~$51.31
#62021 Topps Opening Day Base Set Jo Adell #85
$1.77PSA 10 ~$36.00
#102021 Topps Opening Day Base Set Mike Trout #27
$1.50PSA 10 ~$41.00
Just missed the cut
- #11 2021 Topps Opening Day Base Set Javier Baez #170$1.49
- #12 2021 Topps Opening Day Base Set Nick Solak #102$1.40
- #13 2021 Topps Opening Day Base Set Alec Bohm #62$1.29
- #14 2021 Topps Opening Day Base Set Joey Bart #176$1.29
- #15 2021 Topps Opening Day Base Set Dustin May #138$1.27
- #16 2021 Topps Opening Day Base Set Codi Heuer #35$1.25
- #17 2021 Topps Opening Day Base Set Casey Mize #82$1.25
- #18 2021 Topps Opening Day Base Set Max Kepler #48$1.24
- #19 2021 Topps Opening Day Base Set Joey Votto #66$1.23
- #20 2021 Topps Opening Day Base Set Yu Darvish #5$1.15
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