The 10 Most Valuable 2021 Topps Big League Base Set Baseball Cards
The most valuable 2021 Topps Big League Base Set Baseball card is the 2021 Topps Big League Base Set Bo Bichette #227 at $1.84 as of September 30, 2026.
By Ripbin Research · Updated 2026-09-30 · prices from live market data
Shop 2021 Topps Big League Base Set Baseball cards on eBay
Affiliate — we may earn a commissionThe 10 most valuable 2021 Topps Big League Base Set Baseball cards in the Ripbin catalog carry a combined raw market value of $16.54, topped by a $1.84 card.
#92021 Topps Big League Base Set Pete Alonso #16
$1.58PSA 10 ~$32.50
Just missed the cut
- #11 2021 Topps Big League Base Set Jose Ramirez #235$1.51
- #12 2021 Topps Big League Base Set John Means #117$1.50
- #13 2021 Topps Big League Base Set Kyle Seager #127$1.50
- #14 2021 Topps Big League Base Set Aaron Judge #233$1.50
- #15 2021 Topps Big League Base Set Mike Trout #1$1.47
- #16 2021 Topps Big League Base Set Nick Solak #105$1.46
- #17 2021 Topps Big League Base Set Jose Abreu #266$1.45
- #18 2021 Topps Big League Base Set Shane Bieber #268$1.45
- #19 2021 Topps Big League Base Set Joey Votto #89$1.44
- #20 2021 Topps Big League Base Set Jose Abreu #245$1.43
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